Publications

Stefan N, Sip­pel K, Heni M, Fritsche A, Wag­n­er R, Jakob CEM, Preißl H, Wer­der A, Khodamor­adi Y, Borgmann S, Rüthrich MM, Hanses F, Hasel­ber­ger M, Piepel C, Hower M, vom Dahl J, Wille K, Römmele C, Vehreschild JJ, Stech­er M, Solimena M, Roden M, Schür­mann A, Gall­witz B, Hrabe de Angel­is M, Lud­wig DS, Schulze MB, Jensen BEO, Birken­feld A, on behalf of the LEOSS Study Group. Obesity and impaired meta­bol­ic health increase the risk of COV­ID-19-related mor­tal­ity in young and middle-aged adults to the risk level observed in eld­erly people; the LEOSS registry. Fron­ti­ers in Medi­cine. 2022 May 11. doi: 10.3389/fmed.2022.875430

Pil­gram L, Eber­wein L, Jensen BEO, Jakob CM, Koehler FC, Hower M, Kiel­stein JT, Stech­er M, Hohen­stein B, Prass­er F, West­hoff T„ Nunes de Mir­anda SM, Vehreschild MJGT, Lan­znas­ter J, Dolff S, LEOSS study group. SARS-CoV­‑2 infec­tion in chron­ic kid­ney dis­ease patients with pre-exist­ing dia­lys­is: descrip­tion across dif­fer­ent pan­dem­ic inter­vals and effect on dis­ease course (mor­tal­ity). Infec­tion. 2022. Apr 29. 1–11.

Broz­at JF, Hanses F, Hael­ber­ger M, Stech­er M, Dre­her M, Tometten L, Ruethrich MM, Vehreschild JJ, Traut­wein C, Borgmann S, Vehreschild MJGT, Jakob CEM, Stall­mach A, Wille K, Hell­wig K, Isbern­er N, Reuk­en PA, Geisler F, Nat­ter­mann J, Bruns T, the LEOSS study. COVID-​19 mor­tal­ity in cir­rhosis is determ­ined by cirrhosis-​associated comor­bid­it­ies and extra­hep­at­ic organ fail­ure: Res­ults from the mul­tina­tion­al LEOSS registry. United European Gast­roen­ter­o­logy Journ­al, 1–16. 2022 Apr 28, doi: 10.1002/ueg2.12232

Linden T, Hanses F, Fernán­dez DD, DeLong LN, Koda­mul­lil AT, Schneider J, Vehreschild MJGT, Lan­znas­ter J, Ruethrich MM, Borgmann S, Hower M, Wille K, Feldt T, Rieg S, Her­ten­stein B, Wyen C, Roemmele C, Vehreschild JJ, Jakob CEM, Stech­er M, Kuzikov M, Zaliani A, Fröh­lich H, LEOSS study group. Machine learn­ing based pre­dic­tion of COVID-19 mor­tal­ity sug­gests repos­i­tion­ing of anti­c­an­cer drug for treat­ing severe cases. 2021 Nov 12. Arti­fi­cial Intel­li­gence in the Life Sci­ences doi: 10.1101/2021.11.11.21266048

Pil­gram L, Schons M, Jakob CM, Claßen AY, Franke B, Tscharntke L, Schulze N, Fuhr­mann S, Sauer G, Nunes de Mir­anda SM, Prass­er F, Stech­er M, Vehreschild JJ, : The COVID-19 pan­dem­ic as an oppor­tun­ity and chal­lenge for regis­tries in health ser­vices research: Les­sons learned in the Lean European Open Sur­vey on SARS-CoV­‑2 Infec­ted Patients (LEOSS). Gesund­heit­swesen 2021 Nov 3; 83(S 01): S45-S53. doi: 10.1055/a‑1655–8705

Cre­mer S, Pil­gram L, Berkow­itsch A, Stech­er M, Rieg S, Shum­liakivska M, Bojkova D,
Wag­n­er JUG, Ser­vet Aslan G, Spin­ner C, Lux­an G, Hanses F, Dolff S, Piepel C, Rup­pert C, Guen­ther A, Rüthrich MM, Vehreschild JJ, Wille K, Hasel­ber­ger M, Heuzeroth H, Hansen A, Eschen­ha­gen T, Cin­atl J, Ciesek S, Dimmel­er S, Borgmann S, Zei­h­er A, LEOSS study group. Angiotensin II recept­or block­er intake asso­ci­ates with reduced mark­ers of inflam­mat­ory activ­a­tion and decreased mor­tal­ity in patients with car­di­ovas­cu­lar comor­bid­it­ies and COVID-19 dis­ease. PLOS One. 2021 Oct 21 doi:/10.1371/journal.pone.0258684

Stephan Zellmer, Frank Hanses, Anna Muzalyova, Johanna Classen, Georg Braun, Chris­ti­ane Piepel, Johanna Erber, Lisa Pil­gram, Lorenz Wal­ter, Siri Göpel, Kai Wille, Mar­tin Hower, Maria Madeleine Rüthrich , Jan Rupp, Chris­ti­an Degen­hardt, Ingo Voigt, Stefan Borgmann, Melanie Stech­er, Car­olin Jakob, Christine Dhil­lon, Helmut Mess­mann, Alanna Ebigbo, Chris­toph Römmele, LEOSS study group. Gastrointest­in­al bleed­ing and endo­scop­ic find­ings in crit­ic­ally and non-crit­ic­ally ill patients with corona vir­us dis­ease 2019 (COVID-19): Res­ults from Lean European Open Sur­vey on SARS-CoV­‑2 (LEOSS) and COKA regis­tries. United European Gast­roen­ter­ol J. 2021 Oct 15. doi: 10.1002/ueg2.12165. PMID: 34655180 DOI: 10.1002/ueg2.12165

Max­imili­an J Schons, Amke Caliebe, Chris­toph D Spin­ner, Annika Y Classen, Lisa Pil­gram, Maria M Ruethrich, Jan Rupp, Susana Nunes de Mir­anda, Chris­toph Römmele, Janne Vehreschild, Bjo­ern-Erik Jensen, Maria Vehreschild, Chris­ti­an Degen­hardt, Stefan Borgmann, Mar­tin Hower, Frank Hanses, Mar­tina Hasel­ber­ger, Anette K Friedrichs, LEOSS-study group. All-cause mor­tal­ity and dis­ease pro­gres­sion in SARS-CoV-2-infec­ted patients with or without anti­bi­ot­ic ther­apy: an ana­lys­is of the LEOSS cohort. Infec­tion. 2021 Oct 8. doi: 10.1007/s15010-021–01699‑2. PMID: 34625912 PMCID: PMC8500268

Mar­ina Rieder, Nad­ine Gauchel, Klaus Kaier, Car­olin Jakob, Stefan Borgmann, Annika Y. Classen, Jochen Schneider, Lukas Eber­wein, Mar­tin Lab­lans, Maria Rüthrich, Sebasti­an Dolff, Kai Wille, Mar­tina Hasel­ber­ger, Han­no Heuzeroth, Chris­toph Bode, Con­stantin von zur Müh­len, Siegbert Rieg & Daniel Duer­schmied. Pre-med­ic­a­tion with oral anti­co­agu­lants is asso­ci­ated with bet­ter out­comes in a large mul­tina­tion­al COVID-19 cohort with car­di­ovas­cu­lar comor­bid­it­ies. Clin­ic­al Research in Car­di­ology (2021). doi: 10.1007/s00392-021–01939‑3

Mein­trup D, Borgmann S, Seidl K, Stech­er M, Jakob CEM, Pil­gram L, Spin­ner CD, Rieg S, Isbern­er N, Hower M, Vehreschild M, Göpel S, Hanses F, Nowak-Machen M, LEOSS Study Group. Spe­cif­ic Risk Factors for Fatal Out­come in Crit­ic­ally Ill COVID-19 Patients: Res­ults from a European Mul­ti­cen­ter Study. J. Clin. Med. 2021, 10(17), 3855; doi.org/10.3390/jcm10173855

Kleine­berg NN, Knauss S, Gülke E, Pinnschmidt HO, Jakob CEM, Lingor P, Hell­wig K, Ber­thele A, Höglinger G, Fink GR, Endres M, Ger­loff C, Klein C, Stech­er M, Classen AY, Rieg S, Borgmann S, Hanses F, Rüthrich MM, Hower M, Tometten L, Hasel­ber­ger M, Piepel C, Merle U, Dolff S, Degen­hardt C, Jensen BEO, Vehreschild M, Erber J, Franke C, Warnke C, LEOSS Study Group. Neur­o­lo­gic­al symp­toms and com­plic­a­tions in pre­dom­in­antly hos­pit­al­ized COVID-19 patients – res­ults of the European mul­tina­tion­al LEOSS registry. Eur J Neur­ol. 2021 Aug 9. doi: 10.1111/ene.15072

Wer­fel S, Jakob CEM, Borgmann S, Schneider J, Spin­ner C, Schons M, Hower M, Wille K, Hasel­ber­ger M7, Heuzeroth H8, Rüthrich MM, Dolff S, Kes­sel J, Heemann U, Vehreschild JJ, Rieg S, Schma­der­er C1, LEOSS study group. Devel­op­ment and Val­id­a­tion of a Sim­pli­fied Risk Score for the Pre­dic­tion of Crit­ic­al COVID-19 Ill­ness in Newly Dia­gnosed Patients. Journ­al of Med­ic­al Vir­o­logy, 31 Jul 2021. doi: 10.1002/jmv.27252. PMID: 34331717. PMCID: PMC8426905

Jakob CEM, Mahajan Mukund U, Oswald M, Stech­er M, Schons M, May­erle J, Rieg S, Pletz M, Merle U, Wille K, Borgmann S, Spin­ner CD, Dolff S, Scher­er C, Pil­gram L, Rüthrich M, Hanses F, Hower M, Strauß R, Mass­berg S, Er Görkem A, Jung N, Vehreschild J J, Stubbe H, Tometten L, König R; LEOSS Study Group. Pre­dic­tion of COVID-19 deteri­or­a­tion in high-risk patients at dia­gnos­is: an early warn­ing score for advanced COVID-19 developed by machine learn­ing. Infec­tion. 2021 Jul 13. doi: 10.1007/s15010-021–01656‑z

KÜHN, Mar­tin J., et al. Assess­ment of effect­ive mit­ig­a­tion and pre­dic­tion of the spread of SARS-CoV­‑2 in Ger­many using demo­graph­ic inform­a­tion and spa­tial res­ol­u­tion. Math­em­at­ic­al Bios­ciences, 2021, S. 108648.

Pil­gram L, Eber­wein L, Wille K, Koehler FC, Stech­er M, Rieg S, Kiel­stein JT, Jakob CEM, Rüthrich M, Burst V, Prass­er F, Borgmann S, Müller RU, Lan­znas­ter J, Isbern­er N, Tometten L, Dolff S; LEOSS Study group. Clin­ic­al course and pre­dict­ive risk factors for fatal out­come of SARS-CoV­‑2 infec­tion in patients with chron­ic kid­ney dis­ease. Infec­tion. 2021 Apr 13. doi: 10.1007/s15010-021–01597‑7. Epub ahead of print. PMID: 33851328.

Huber, M.K., Raichle, C., Lingor, P., Syn­ofzik, M., Borgmann, S., Erber, J., Tometten, L., Rimili, W., Dolff, S., Wille, K., Knauss, S., Piepel, C., Lan­znas­ter, J., Rieg, S., Prass­er, F., Pil­gram, L., Spot­tke, A., Klock­geth­er, T., Klein, C., Hop­fn­er, F., Höglinger, G.U. and (2021), Out­comes of SARS-​CoV-​2 Infec­tions in Patients With Neuro­de­gen­er­at­ive Dis­eases in the LEOSS Cohort. Mov Dis­ord, 2021 Feb­ru­ary 17. doi: 10.1002/mds.28554

Jakob CEM, Kohl­may­er F, Meur­ers T, Vehreschild JJ, Prass­er F. Design and eval­u­ation of a data anonym­iz­a­tion pipeline to pro­mote Open Sci­ence on COVID-19. Sci Data. 2020 Dec 10;7(1):435. doi: 10.1038/s41597-020–00773‑y. PMID: 33303746; PMCID: PMC7729909

Cre­mer S, Jakob C, Berkow­itsch A, Borgmann S, Pil­gram L, Tometten L,  Classen A, Wille K, Weid­lich S, Gruen­er B, Dimmel­er S, Mass­berg S, Rieg  S, Zei­h­er AM; LEOSS study group. Elev­ated mark­ers of thrombo-inflam­mat­ory activ­a­tion pre­dict out­come in patients with car­di­ovas­cu­lar comor­bid­it­ies and COVID-19 dis­ease: insights from the LEOSS registry. Clin Res Car­di­ol. 2020 Nov 19:1–12. doi: 10.1007/s00392-020–01769‑9. Epub ahead of print. PMID: 33211155; PMCID:  PMC7674577.

Hugo C, Strass­burg C, Stech­er M, Rah­mel A. Stable and safe organ pro­cure­ment and trans­plant­a­tion dur­ing SARS-CoV­‑2 pan­dem­ic in Ger­many. Trans­pl Int. 2020 Oct;33(10):1335–1336. doi: 10.1111/tri.13704. Epub  2020 Aug 12. PMID: 32697364; PMCID: PMC7405468.

Rüthrich MM, Giessen-Jung C, Borgmann S, Classen AY, Dolff S, Grün­er B, Hanses F, Isbern­er N, Köhler P, Lan­znas­ter J, Merle U, Nadal­in S, Piepel C, Schneider J, Schons M, Strauss R, Tometten L, Vehreschild JJ, von Lili­en­feld-Toal M, Beutel G, Wille K; LEOSS Study Group. COVID-19 in can­cer patients: clin­ic­al char­ac­ter­ist­ics and out­come – an ana­lys­is of the LEOSS registry. Ann Hem­at­ol. 2020 Nov 7:1–11. doi: 10.1007/s00277-020–04328‑4. Epub ahead of print. PMID: 33159569; PMCID: PMC7648543.

Jakob CEM, Borgmann S, Duy­gu F, Behrends U, Hower M, Merle U, Friedrichs A, Tometten L, Hanses F, Jung N, Rieg S, Wille K, Grün­er B, Klinker H, Gers­bach­er-Runge N, Hell­wig K, Eber­wein L, Dolff S, Rauschning D, von Bergwelt-Bail­don M, Lan­znas­ter J, Strauß R, Trau­th J, de With K, Ruethrich M, Lueck C, Nat­ter­mann J, Tscharntke L, Pil­gram L, Fuhr­mann S, Classen A, Stech­er M, Schons M, Spin­ner C, Vehreschild JJ. First res­ults of the “Lean European Open Sur­vey on SARS-CoV-2-Infec­ted Patients (LEOSS)”. Infec­tion. 2020 Oct 1:1–11. doi: 10.1007/s15010-020–01499‑0. Epub ahead of print. PMID: 33001409; PMCID: PMC7527665.

Schoser B, Baum P, Boen­tert M, Dill­mann K, Emmer A, Knauss S, Enax-Kru­mova E, Grosskreutz J,  Gütt­sches A,  Hell­wig K,  Holza­p­fel K, Korn­blum C, Lehmann H, Melms A,  Mey­er T,  Petri S, Pil­gram L, Rein­ers K,  Saak A, Schäfer J, Schmidt J, Schneider-Gold C, Schons M, Urb­an PP, Vor­gerd M, Young P, Zierz S. SARS-CoV­‑2/­COV­ID-19 und neur­omuskuläre Erkrankun­gen. DGNeur­o­lo­gie 3, 310–320. 2020 May 18. doi: 10.1007/s42451-020–00198‑2.