Hello! Here you can find the amazing work and publications that have resulted from the great cross-site collaboration of many research teams.
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Tscharntke LT, Jung N, Hanses F, Koll CEM, Pilgram L, Rieg S, Borgmann S, de Miranda SMN, Scherer M, Spinner CD, Rüthrich M, Vehreschild MJGT, von Bergwelt-Baildon M, Wille K, Merle U, Hower M, Rothfuss K, Nadalin S, Klinker H, Fürst J, Greiffendorf I, Raichle C, Friedrichs A, Rauschning D, de With K, Eberwein L, Riedel C, Milovanovic M, Worm M, Schultheis B, Schubert J, Bota M, Beutel G, Glück T, Schmid M, Wintermantel T, Peetz H, Steiner S, Ribel E, Schäfer H, Vehreschild JJ, Stecher M; LEOSS Study Group. Role and benefits of infectious diseases specialists in the COVID-19 pandemic: Multilevel analysis of care provision in German hospitals using data from the Lean European Open Survey on SARS-CoV‑2 infected patients (LEOSS) cohort. Infection. 2024 Aug 16. doi: 10.1007/s15010-024–02362‑2. Epub ahead of print. PMID: 39150640.
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Stellmach C, Hopff SM, Jaenisch T, Nunes de Miranda SM, Rinaldi E; NAPKON, LEOSS, ORCHESTRA, and ReCoDID Working Groups. Creation of Standardized Common Data Elements for Diagnostic Tests in Infectious Disease Studies: Semantic and Syntactic Mapping. J Med Internet Res. 2024 Jun 10;26:e50049. doi: 10.2196÷50049. PMID: 38857066; PMCID: PMC11196918.
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Hasseli R, Hanses F, Stecher M, Specker C, Weise T, Borgmann S, Hasselberger M, Hertenstein B, Hower M, Hoyer BF, Koll C, Krause A, von Lilienfeld-Toal M, Lorenz HM, Merle U, Nunes de Miranda SM, Pletz MW, Regierer AC, Richter JG, Rieg S, Roemmele C, Ruethrich MM, Schmeiser T, Schulze-Koops H, Strangfeld A, Vehreschild MJGT, Voit F, Voll RE, Vehreschild JJ, Müller-Ladner U, Pfeil A. The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population‑A comparison of two German registries. Front Med (Lausanne). 2024 Mar 6;11:1332716. doi: 10.3389/fmed.2024.1332716. PMID: 38510457; PMCID: PMC10953502.
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Rüthrich MM, Khodamoradi Y, Lanznaster J, Stecher M, Tometten L, Voit F, Koll CEM, Borgmann S, Vehreschild JJ, Ole Jensen BE, Hanses F, Giessen-Jung C, Wille K, von Lilienfeld-Toal M, Beutel G; LEOSS Study Group. COVID-19 in Patients with Active Cancer: Higher Inflammatory Activity Predicts Poor Outcome. Oncol Res Treat. 2024;47(3):88–96. doi: 10.1159÷000535267. Epub 2023 Nov 15. PMID: 37967545.
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Bartenschlager CC, Grieger M, Erber J, Neidel T, Borgmann S, Vehreschild JJ, Steinbrecher M, Rieg S, Stecher M, Dhillon C, Ruethrich MM, Jakob CEM, Hower M, Heller AR, Vehreschild M, Wyen C, Messmann H, Piepel C, Brunner JO, Hanses F, Römmele C; LEOSS study group. Covid-19 triage in the emergency department 2.0: how analytics and AI transform a human-made algorithm for the prediction of clinical pathways. Health Care Manag Sci. 2023 Sep;26(3):412–429. doi: 10.1007/s10729-023–09647‑2. Epub 2023 Jul 10. PMID: 37428304; PMCID: PMC10485125.
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Bartenschlager CC, Ebel SS, Kling S, Vehreschild J, Zabel LT, Spinner CD, Schuler A, Heller AR, Borgmann S, Hoffmann R, Rieg S, Messmann H, Hower M, Brunner JO, Hanses F, Römmele C. COVIDAL: A Machine Learning Classifier for Digital COVID-19 Diagnosis in German Hospitals. ACM Trans. Manage. Inf. Syst. 2023 Mar;14(2):14. doi.org/10.1145/3567431.
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de Hesselle ML, Borgmann S, Rieg S, Vehreschild JJ, Rasch S, Koll CEM, Hower M, Stecher M, Ebert D, Hanses F, Schumann J, On Behalf Of The Leoss Study Group. Age and Comorbidity Burden of Patients Critically Ill with COVID-19 Affect Both Access to and Outcome of Ventilation Therapy in Intensive Care Units. J Clin Med. 2023 Mar 24;12(7):2469. doi: 10.3390/jcm12072469. PMID: 37048553; PMCID: PMC10095412.
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Mascaro S, Wu Y, Woodberry O, Nyberg EP, Pearson R, Ramsay JA, Mace AO, Foley DA, Snelling TL, Nicholson AE; COVID BN Advisory Group. Modeling COVID-19 disease processes by remote elicitation of causal Bayesian networks from medical experts. BMC Med Res Methodol. 2023 Mar 29;23(1):76. doi: 10.1186/s12874-023–01856‑1. PMID: 36991342; PMCID: PMC10050813.
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Schmidt-Hellerau K, Raichle C, Ruethrich MM, Vehreschild JJ, Lanznaster J, Nunes de Miranda SM, Bausewein C, Vehreschild MJGT, Koll CEM, Simon ST, Hellwig K, Jensen BO, Jung N; LEOSS Study Group. Specialized palliative care for hospitalized patients with SARS-CoV‑2 infection: an analysis of the LEOSS registry. Infection. 2023 Aug;51(4):1119–1126. doi: 10.1007/s15010-023–02020‑z. Epub 2023 Mar 23. PMID: 36952127; PMCID: PMC10034879.
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Koppe U, Schilling J, Stecher M, Rüthrich MM, Marquis A, Diercke M, Haselberger M, Koll CEM, Niebank M, Ruehe B, Borgmann S, Grabenhenrich L, Hellwig K, Pilgram L, Spinner CD, Paerisch T; LEOSS study group. Disease severity in hospitalized COVID-19 patients: comparing routine surveillance with cohort data from the LEOSS study in 2020 in Germany. BMC Infect Dis. 2023 Feb 10;23(1):89. doi: 10.1186/s12879-023–08035‑z. PMID: 36765274; PMCID: PMC9912207.
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Pilgram L, Appel KS, Ruethrich MM, Koll CEM, Vehreschild MJGT, de Miranda SMN, Hower M, Hellwig K, Hanses F, Wille K, Haselberger M, Spinner CD, Vom Dahl J, Hertenstein B, Westhoff T, Vehreschild JJ, Jensen BO, Stecher M. Use and effectiveness of remdesivir for the treatment of patients with covid-19 using data from the Lean European Open Survey on SARS-CoV‑2 infected patients (LEOSS): a multicentre cohort study. Infection. 2023 Aug;51(4):1033–1049. doi: 10.1007/s15010-023–01994‑0. Epub 2023 Feb 10. PMID: 36763285; PMCID: PMC9913009.
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Freise NF, Gliga S, Fischer J, Lübke N, Lutterbeck M, Schöler M, Bölke E, Orth HM, Feldt T, Roemmele C, Wilke D, Schneider J, Wille K, Hohmann C, Strauss R, Hower M, Ruf A, Schubert J, Isberner N, Stecher M, Pilgram L, Vehreschild JJ; LEOSS Study Group; Hanses F, Luedde T, Jensen B. Convalescent plasma treatment for SARS-CoV‑2 infected high-risk patients: a matched pair analysis to the LEOSS cohort. Sci Rep. 2022 Nov 9;12(1):19035. doi: 10.1038/s41598-022–23200‑1. PMID: 36351986; PMCID: PMC9643921.
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Heissig B, Salama Y, Iakoubov R, Vehreschild JJ, Rios R, Nogueira T, Vehreschild MJGT, Stecher M, Mori H, Lanznaster J, Adachi E, Jakob C, Tabe Y, Ruethrich M, Borgmann S, Naito T, Wille K, Valenti S, Hower M, Hattori N, Rieg S, Nagaoka T, Jensen BE, Yotsuyanagi H, Hertenstein B, Ogawa H, Wyen C, Kominami E, Roemmele C, Takahashi S, Rupp J, Takahashi K, Hanses F, Hattori K; LEOSS Study Group. COVID-19 Severity and Thrombo-Inflammatory Response Linked to Ethnicity. Biomedicines. 2022 Oct 12;10(10):2549. doi.org/10.3390/biomedicines10102549.
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de Hesselle ML, Borgmann S, Rieg S, Vehreshild JJ, Spinner CD, Koll CEM, Hower M, Stecher M, Ebert D, Hanses F, Schumann J; LEOSS Study Group. Invasiveness of Ventilation Therapy Is Associated to Prevalence of Secondary Bacterial and Fungal Infections in Critically Ill COVID-19 Patients. J Clin Med. 2022 Sep 5;11(17):5239. doi: 10.3390/jcm11175239. PMID: 36079168; PMCID: PMC9457079.
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Raichle C, Borgmann S, Bausewein C, Rieg S, Jakob CEM, Simon ST, Tometten L, Vehreschild JJ, Leisse C, Erber J, Stecher M, Pauli B, Rüthrich MM, Pilgram L, Hanses F, Isberner N, Hower M, Degenhardt C, Hertenstein B, Vehreschild MJGT, Römmele C, Jung N; LEOSS Study Group. Hospitalized patients dying with SARS-CoV‑2 infection-An analysis of patient characteristics and management in ICU and general ward of the LEOSS registry. PLoS One. 2022 Jul 29;17(7):e0271822. doi: 10.1371/journal.pone.0271822. PMID: 35905129; PMCID: PMC9337665.
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Stefan N, Sippel K, Heni M, Fritsche A, Wagner R, Jakob CEM, Preißl H, Werder A, Khodamoradi Y, Borgmann S, Rüthrich MM, Hanses F, Haselberger M, Piepel C, Hower M, vom Dahl J, Wille K, Römmele C, Vehreschild JJ, Stecher M, Solimena M, Roden M, Schürmann A, Gallwitz B, Hrabe de Angelis M, Ludwig DS, Schulze MB, Jensen BEO, Birkenfeld A, on behalf of the LEOSS Study Group. Obesity and impaired metabolic health increase the risk of COVID-19-related mortality in young and middle-aged adults to the risk level observed in elderly people; the LEOSS registry. Frontiers in Medicine. 2022 May 11. doi: 10.3389/fmed.2022.875430.
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Pilgram L, Eberwein L, Jensen BEO, Jakob CM, Koehler FC, Hower M, Kielstein JT, Stecher M, Hohenstein B, Prasser F, Westhoff T„ Nunes de Miranda SM, Vehreschild MJGT, Lanznaster J, Dolff S, LEOSS study group. SARS-CoV‑2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality). Infection. 2022. Apr 29. 1–11.
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Brozat JF, Hanses F, Haelberger M, Stecher M, Dreher M, Tometten L, Ruethrich MM, Vehreschild JJ, Trautwein C, Borgmann S, Vehreschild MJGT, Jakob CEM, Stallmach A, Wille K, Hellwig K, Isberner N, Reuken PA, Geisler F, Nattermann J, Bruns T, the LEOSS study. COVID-19 mortality in cirrhosis is determined by cirrhosis-associated comorbidities and extrahepatic organ failure: Results from the multinational LEOSS registry. United European Gastroenterology Journal, 1–16. 2022 Apr 28, doi: 10.1002/ueg2.12232.
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Linden T, Hanses F, Fernández DD, DeLong LN, Kodamullil AT, Schneider J, Vehreschild MJGT, Lanznaster J, Ruethrich MM, Borgmann S, Hower M, Wille K, Feldt T, Rieg S, Hertenstein B, Wyen C, Roemmele C, Vehreschild JJ, Jakob CEM, Stecher M, Kuzikov M, Zaliani A, Fröhlich H, LEOSS study group. Machine learning based prediction of COVID-19 mortality suggests repositioning of anticancer drug for treating severe cases. 2021 Nov 12. Artificial Intelligence in the Life Sciences doi: 10.1101/2021.11.11.21266048.
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Pilgram L, Schons M, Jakob CM, Claßen AY, Franke B, Tscharntke L, Schulze N, Fuhrmann S, Sauer G, Nunes de Miranda SM, Prasser F, Stecher M, Vehreschild JJ, : The COVID-19 pandemic as an opportunity and challenge for registries in health services research: Lessons learned in the Lean European Open Survey on SARS-CoV‑2 Infected Patients (LEOSS). Gesundheitswesen 2021 Nov 3; 83(S 01): S45-S53. doi: 10.1055/a‑1655–8705.
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Cremer S, Pilgram L, Berkowitsch A, Stecher M, Rieg S, Shumliakivska M, Bojkova D,
Wagner JUG, Servet Aslan G, Spinner C, Luxan G, Hanses F, Dolff S, Piepel C, Ruppert C, Guenther A, Rüthrich MM, Vehreschild JJ, Wille K, Haselberger M, Heuzeroth H, Hansen A, Eschenhagen T, Cinatl J, Ciesek S, Dimmeler S, Borgmann S, Zeiher A, LEOSS study group. Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease. PLOS One. 2021 Oct 21 doi:/10.1371/journal.pone.0258684.
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Zellmer S, Hanses F, Muzalyova A, Classen J, Braun G, Piepel C, Erber J, Pilgram L, Walter L, Göpel S, Wille K, Hower M, Rüthrich MM, Rupp J, Degenhardt C, Voigt I, Borgmann S, Stecher M, Jakob C, Dhillon C, Messmann H, Ebigbo A, Römmele C; LEOSS study group. Gastrointestinal bleeding and endoscopic findings in critically and non-critically ill patients with corona virus disease 2019 (COVID-19): Results from Lean European Open Survey on SARS-CoV‑2 (LEOSS) and COKA registries. United European Gastroenterol J. 2021 Oct 15. doi: 10.1002/ueg2.12165. PMID: 34655180 DOI: 10.1002/ueg2.12165.
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Schons MJ, Caliebe A, Spinner CD, Classen AY, Pilgram L, Ruethrich MM, Rupp J, Nunes de Miranda SM, Römmele C, Vehreschild J, Jensen BE, Vehreschild M, Degenhardt C, Borgmann S, Hower M, Hanses F, Haselberger M, Friedrichs AK; LEOSS-study group. All-cause mortality and disease progression in SARS-CoV-2-infected patients with or without antibiotic therapy: an analysis of the LEOSS cohort. Infection. 2021 Oct 8:1–14. doi: 10.1007/s15010-021–01699‑2.
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Rieder M, Gauchel N, Kaier K, Jakob C, Borgmann S, Classen AY, Schneider J, Eberwein L, Lablans M, Rüthrich M, Dolff S, Wille K, Haselberger M, Heuzeroth H, Bode C, von Zur Mühlen C, Rieg S, Duerschmied D. Pre-medication with oral anticoagulants is associated with better outcomes in a large multinational COVID-19 cohort with cardiovascular comorbidities. Clin Res Cardiol. 2021 Sep 21:1–11. doi: 10.1007/s00392-021–01939‑3. Epub ahead of print. PMID: 34546427; PMCID: PMC8453472.
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Meintrup D, Borgmann S, Seidl K, Stecher M, Jakob CEM, Pilgram L, Spinner CD, Rieg S, Isberner N, Hower M, Vehreschild M, Göpel S, Hanses F, Nowak-Machen M, LEOSS Study Group. Specific Risk Factors for Fatal Outcome in Critically Ill COVID-19 Patients: Results from a European Multicenter Study. J. Clin. Med. 2021, 10(17), 3855; doi.org/10.3390/jcm10173855.
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Kleineberg NN, Knauss S, Gülke E, Pinnschmidt HO, Jakob CEM, Lingor P, Hellwig K, Berthele A, Höglinger G, Fink GR, Endres M, Gerloff C, Klein C, Stecher M, Classen AY, Rieg S, Borgmann S, Hanses F, Rüthrich MM, Hower M, Tometten L, Haselberger M, Piepel C, Merle U, Dolff S, Degenhardt C, Jensen BEO, Vehreschild M, Erber J, Franke C, Warnke C, LEOSS Study Group. Neurological symptoms and complications in predominantly hospitalized COVID-19 patients – results of the European multinational LEOSS registry. Eur J Neurol. 2021 Aug 9. doi: 10.1111/ene.15072.
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Kühn MJ, Abele D, Mitra T, Koslow W, Abedi M, Rack K, Siggel M, Khailaie S, Klitz M, Binder S, Spataro L, Gilg J, Kleinert J, Häberle M, Plötzke L, Spinner CD, Stecher M, Zhu XX, Basermann A, Meyer-Hermann M. Assessment of effective mitigation and prediction of the spread of SARS-CoV‑2 in Germany using demographic information and spatial resolution. Mathematical Biosciences. 2021, Volume 339, Article 108648. doi: 10.1016/j.mbs.2021.108648.
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Werfel S, Jakob CEM, Borgmann S, Schneider J, Spinner C, Schons M, Hower M, Wille K, Haselberger M7, Heuzeroth H8, Rüthrich MM, Dolff S, Kessel J, Heemann U, Vehreschild JJ, Rieg S, Schmaderer C1, LEOSS study group. Development and Validation of a Simplified Risk Score for the Prediction of Critical COVID-19 Illness in Newly Diagnosed Patients. Journal of Medical Virology, 31 Jul 2021. doi: 10.1002/jmv.27252. PMID: 34331717. PMCID: PMC8426905.
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Jakob CEM, Mahajan Mukund U, Oswald M, Stecher M, Schons M, Mayerle J, Rieg S, Pletz M, Merle U, Wille K, Borgmann S, Spinner CD, Dolff S, Scherer C, Pilgram L, Rüthrich M, Hanses F, Hower M, Strauß R, Massberg S, Er Görkem A, Jung N, Vehreschild J J, Stubbe H, Tometten L, König R; LEOSS Study Group. Prediction of COVID-19 deterioration in high-risk patients at diagnosis: an early warning score for advanced COVID-19 developed by machine learning. Infection. 2021 Jul 13. doi: 10.1007/s15010-021–01656‑z.
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Pilgram L, Eberwein L, Wille K, Koehler FC, Stecher M, Rieg S, Kielstein JT, Jakob CEM, Rüthrich M, Burst V, Prasser F, Borgmann S, Müller RU, Lanznaster J, Isberner N, Tometten L, Dolff S; LEOSS Study group. Clinical course and predictive risk factors for fatal outcome of SARS-CoV‑2 infection in patients with chronic kidney disease. Infection. 2021 Apr 13. doi: 10.1007/s15010-021–01597‑7. Epub ahead of print. PMID: 33851328.
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Huber, M.K., Raichle, C., Lingor, P., Synofzik, M., Borgmann, S., Erber, J., Tometten, L., Rimili, W., Dolff, S., Wille, K., Knauss, S., Piepel, C., Lanznaster, J., Rieg, S., Prasser, F., Pilgram, L., Spottke, A., Klockgether, T., Klein, C., Hopfner, F., Höglinger, G.U. and (2021), Outcomes of SARS-CoV-2 Infections in Patients With Neurodegenerative Diseases in the LEOSS Cohort. Mov Disord, 2021 February 17. doi: 10.1002/mds.28554.
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Jakob CEM, Kohlmayer F, Meurers T, Vehreschild JJ, Prasser F. Design and evaluation of a data anonymization pipeline to promote Open Science on COVID-19. Sci Data. 2020 Dec 10;7(1):435. doi: 10.1038/s41597-020–00773‑y. PMID: 33303746; PMCID: PMC7729909.
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Cremer S, Jakob C, Berkowitsch A, Borgmann S, Pilgram L, Tometten L, Classen A, Wille K, Weidlich S, Gruener B, Dimmeler S, Massberg S, Rieg S, Zeiher AM; LEOSS study group. Elevated markers of thrombo-inflammatory activation predict outcome in patients with cardiovascular comorbidities and COVID-19 disease: insights from the LEOSS registry. Clin Res Cardiol. 2020 Nov 19:1–12. doi: 10.1007/s00392-020–01769‑9. Epub ahead of print. PMID: 33211155; PMCID: PMC7674577.
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Hugo C, Strassburg C, Stecher M, Rahmel A. Stable and safe organ procurement and transplantation during SARS-CoV‑2 pandemic in Germany. Transpl Int. 2020 Oct;33(10):1335–1336. doi: 10.1111/tri.13704. Epub 2020 Aug 12. PMID: 32697364; PMCID: PMC7405468.
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Rüthrich MM, Giessen-Jung C, Borgmann S, Classen AY, Dolff S, Grüner B, Hanses F, Isberner N, Köhler P, Lanznaster J, Merle U, Nadalin S, Piepel C, Schneider J, Schons M, Strauss R, Tometten L, Vehreschild JJ, von Lilienfeld-Toal M, Beutel G, Wille K; LEOSS Study Group. COVID-19 in cancer patients: clinical characteristics and outcome – an analysis of the LEOSS registry. Ann Hematol. 2020 Nov 7:1–11. doi: 10.1007/s00277-020–04328‑4. Epub ahead of print. PMID: 33159569; PMCID: PMC7648543.
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Jakob CEM, Borgmann S, Duygu F, Behrends U, Hower M, Merle U, Friedrichs A, Tometten L, Hanses F, Jung N, Rieg S, Wille K, Grüner B, Klinker H, Gersbacher-Runge N, Hellwig K, Eberwein L, Dolff S, Rauschning D, von Bergwelt-Baildon M, Lanznaster J, Strauß R, Trauth J, de With K, Ruethrich M, Lueck C, Nattermann J, Tscharntke L, Pilgram L, Fuhrmann S, Classen A, Stecher M, Schons M, Spinner C, Vehreschild JJ. First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”. Infection. 2020 Oct 1:1–11. doi: 10.1007/s15010-020–01499‑0. Epub ahead of print. PMID: 33001409; PMCID: PMC7527665.
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Schoser B, Baum P, Boentert M, Dillmann K, Emmer A, Knauss S, Enax-Krumova E, Grosskreutz J, Güttsches A, Hellwig K, Holzapfel K, Kornblum C, Lehmann H, Melms A, Meyer T, Petri S, Pilgram L, Reiners K, Saak A, Schäfer J, Schmidt J, Schneider-Gold C, Schons M, Urban PP, Vorgerd M, Young P, Zierz S. SARS-CoV‑2/COVID-19 und neuromuskuläre Erkrankungen. DGNeurologie 3, 310–320. 2020 May 18. doi: 10.1007/s42451-020–00198‑2.
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